BDBM35254 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine::CHEMBL715::Olansek::US8802672, Olanzapine::Zyprexa::olanzapine

SMILES CN1CCN(CC1)C1=Nc2ccccc2Nc2sc(C)cc12

InChI Key InChIKey=KVWDHTXUZHCGIO-UHFFFAOYSA-N

Data  180 KI  19 IC50  1 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 35254   

TargetD(4) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]spiperone from human dopamine D4.4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(4) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  28nMAssay Description:Binding affinity towards human dopamine receptor D4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(4) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  28nMAssay Description:Inhibition of human dopamine D4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(4) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  28nMAssay Description:Binding affinity towards human dopamine-4.2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(4) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  29nMAssay Description:Binding affinity towards human Dopamine receptor D4.2 in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(4) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  50nMAssay Description:Binding affinity to human cloned dopamine D4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(4) dopamine receptor(RAT)
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  50nMAssay Description:Displacement of [3H]N-methylspiperone from rat dopamine D4 receptor by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataIC50:  173nMAssay Description:Inhibitory concentration against human Dopamine receptor D4.2 in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank